The Role of Integrated Approach in the Determination of Nanoparticle Sizes in Dispersions

Abstract Aqueous dispersions of gold and silver nanoparticles (NPs) stabilized with sodium citrate, as well polymeric NPs based on poly(lactide- co -glycolide) (70 : 30 mol %) poly(vinyl alcohol) have been obtained. The sizes determined by transmission electron microscopy (TEM), dynamic light scattering (DLS), analytical ultracentrifugation (AUC). It has shown that the diameter both metallic particles measured TEM is significantly lower than their hydrodynamic D h DLS. Moreover, it found value obtained for studied from DLS distributions overestimated compared to AUC, because AUC method less sensitive particle size polydispersity presence large objects in a dispersion.